Women's Health Initiative — WHI Ancillary Studies
WHI Ancillary Studies
There are a number of ancillary studies associated with WHI. The Madison WHI Center participates in several of these, with research topics ranging from diet and eye health to cognitive and memory studies:
Women’s Health Initiative Memory Study (WHIMS)
[http://www.wfubmc.edu/whims/
]
The Women’s Health Initiative Memory Study (WHIMS) is an ancillary study of the WHI HT arm. The study is designed to assess the effects of hormone replacement therapy on the development and progression of symptoms associated with dementia in approximately 7,480 women, 65 years and older at 39 centers.
- Findings from this study were published in JAMA:
- May 2003 (link: http://www.whi.org/findings/ht/eplusp_whims.php)
- June 2004 (link: http://www.whi.org/findings/ht/ealone_whims.php)
Funding has been obtained to continue following WHIMS participants through 2008.
(Enrollment is limited to previous WHIMS participants.)
WHI-Coronary Artery Calcification (WHI-CACS)
The WHI Coronary Artery Calcium Study (WHI-CACS) is a sub-study of the WHI E-Alone Clinical Trial that seeks to assess the status of coronary atherosclerosis among women aged 50-59 at enrollment. The study utilizes electron beam computed tomography to assess the presence and extent of calcification due to atherosclerosis in the coronary arteries. A total of 900 women were enrolled with half of the women taking estrogen (Premarin .625 mgm) and the other half on placebo. (enrollment closed)
A Randomized Controlled Trial of Fat Reduction, Calcium-Vitamin D supplementation, HRT and risk of proliferative forms of benign breast disease (BBD Study)
This ancillary study of the WHI Clinical Trial seeks to test the hypothesis that adoption of a low-fat dietary pattern is associated with reduced risk of proliferative forms of benign breast disease, that calcium/vitamin D (CaD) supplementation is associated with reduced risk and that use of estrogen replacement therapy (ERT) or combined estrogen/progestogen therapy (PERT) is associated with increased risk of these conditions.
Women in the clinical trial may report breast biopsies on their medical history update forms which are completed yearly. Women reporting a breast procedure are invited to have their breast biopsy slides reviewed without unblinding. (enrollment closed)
Nutritional Biomarker Study (NBS)
The usual dietary assessment instruments, such as those used in the WHI Dietary Modification Trial, may have some bias as they are self-report. The overall objective of the Nutritional Biomarker Study (NBS) was to collect objective (blood and urine) measures of dietary intake to use in the regression calibration models for use in correcting the random and systematic bias of dietary self-report.
550 WHI Dietary Study participants (both intervention and control), including 50 from the Madison WHI Clinical Center were enrolled. The data collected from this 2004 study was used to prepare an R01 funding application to the NIH for a larger study. (enrollment closed)
Effect of a long-term, low-fat, fruit and vegetable diet on retinal carotenoids
This substudy was designed to collect information using heterochromatic flicker photometry to measure macular pigment in the back of the eye of 400 women who had previously participated in the WHI Dietary study (both intervention and control). (enrollment closed)
Mammographic Density in Invasive Breast Cancer
This study is designed to estimate the relative risk for breast cancer associated with a change in mammographic density by comparing prior mammogram films from WHI Hormone Trial participants who have had invasive breast cancer with participants who have not had breast cancer. (enrollment closed)
